Abstract Efficient cytosolic delivery of RNA molecules remains a formidable barrier for RNA therapeutic strategies.Lipid nanoparticles (LNPs) serve as state-of-the-art carriers that can deliver RNA molecules intracellularly, as exemplified by the recent implementation of several vaccines against SARS-CoV-2.Using a bottom-up rational design approach
ABSTRACT Pyroptosis is an inflammatory immune response of eukaryotic cells to bacterial lipopolysaccharide (LPS) and other pathological stimuli, leading to the activation of the gasdermin D (GSDMD) and secretion of pore-forming domain GSDMDNterm, facilitating the release of cytokines.Additionally, GSDMDNterm exhibits antibacterial properties throug
Abstract Pump-and-dump schemes are fraudulent price manipulations through the spread of misinformation and have been around in economic settings since at least the 1700s.With new technologies around copyright trading, the problem has intensified to a shorter time scale and broader scope.The scientific literature on copyright pump-and-dump schemes i
Traditional sweet pepper cultivars showing susceptibility to the Potato virus Y (PVY) are being replaced by resistant hybrids with higher commercial value.Despite of much information about resistance source reaction and their inheritance, there is no knowledge about the genetic background of commercial resistant hybrids.Reaction of sweet pepper (Ca